Parlakgul Lab
University of California, Berkeley

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Research

Metabolism underpins life by driving critical functions such as bioenergetic reactions, the synthesis of essential macromolecules, detoxification, and the maintenance of homeostasis. These processes are fundamental to cellular and organismal viability. However, the biochemical reactions and enzymes are not homogeneously distributed in a cell, but rather compartmentalized in organelles and their specialized sub-domains. The shape, distribution, interaction, and overall organization of organelles in specialized tissues vary at different spatial and temporal scales, enabling them to meet functional demands and adapt to various challenges. We investigate how this specialized, dynamic subcellular organization regulates cellular function at tissue and organism level. We use an interdisciplinary approach ranging from high resolution imaging, computer vision to biochemistry and physiology.

Publications

Selected Publications

Integration of ER protein quality control mechanisms defines β cell function and ER architecture. Shrestha N, Torres M, Zhang J, Lu Y, Haataja L, Reinert RB, Knupp J, Chen YJ, Parlakgul G, Arruda AP, Tsai B, Arvan P, Qi L.

J Clin Invest. 2023 Jan 3;133(1):e163584. doi: 10.1172/JCI163584.

Endoplasmic Reticulum Architecture and Inter-Organelle Communication in Metabolic Health and Disease.

Arruda AP, Parlakgül G. Cold Spring Harb Perspect Biol. 2023 Feb 1;15(2):a041261. doi: 10.1101/cshperspect.a041261.

Regulation of liver subcellular architecture controls metabolic homeostasis.

Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamışlıgil GS.

Nature. 2022 Mar;603(7902):736-742. doi: 10.1038/s41586-022-04488-5.

Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity. Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS.

Science Signaling. 2021 Dec 14;14(713):eabf2059. doi: 10.1126/scisignal.abf2059.

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS.

Nature Medicine. 2018 Mar;24(3):292-303. doi: 10.1038/nm.4481.

Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity. Arruda AP, Pers BM, Parlakgul G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS.

Elife. 2017 Dec 15;6:e29968. doi: 10.7554/eLife.29968.

Type I Interferons Interfere with Liver Glucose Metabolism. Parlakgul G, Hotamisligil GS.

Cell Metabolism. 2017 Jun 6;25(6):1211-1212. doi: 10.1016/j.cmet.2017.05.009.

Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Arruda AP*, Pers BM*, Parlakgül G, Güney E, Inouye K, Hotamisligil GS.

Nature Medicine, 2014, 1427-35. doi: 10.1038/nm.3735.

Simple precision creation of digitally specified, spatially heterogeneous, engineered tissue architectures. Gurkan UA, Fan Y, Xu F, Erkmen B, Urkac ES, Parlakgul G, Bernstein J, Xing W, Boyden ES, Demirci U.

Advanced Materials, 2013 Feb 25;25(8):1192-8. doi: 10.1002/adma.201203261.

Expression of regulatory receptors on γδ T cells and their cytokine production in Behcet's disease.

Parlakgul G, Guney E, Erer B, Kılıcaslan Z, Direskeneli H, Gul A, Saruhan-Direskeneli G.

Arthritis Res Ther. 2013 Jan 21;15(1):R15. doi: 10.1186/ar4147.